Endocrine Abstracts

Background/aims: Prostatic specific antigen (PSA) is the best prostatic tumor marker in man; Recently PSA has been detected in a variety of tissues and fluids in women and is considered a marker of hyperandrogenism. However no precise information are avaible about the physiology of PSA in females. The goal of this study was to assess serum concentrations of PSA in healthy pre-menopausal women (healthy pre-menopausal group) and menopausal women (menopause group) and compare the...

Polycystic Ovary Syndrome (PCOS) is currently believed a common endocrine-plurimetabolic disorder often associated to insulin resistance, diabetes mellitus, hypertension, hyperandrogenism, dyslipidemia and obesity, pathological conditions predisposing to high cardiovascular risk. Oxidative stress and endothelial dysfunction could represent early mechanisms of the cardiovascular risk in patients with PCOS. In order to confirm this hypothesis, 25 young (23.8±1.3 yr), over-w...

Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age often associated with insulin resistance, diabetes mellitus, hyperandrogenism, dislipidemia, obesity and hypertension, pathological conditions predisposing to high cardiovascular risk. Insulin resistant subjects may have higher plasma renin activity and it is well known that aldosterone plays a well-recognized role in the pathophysiology of hypertension and in the development of...

Background & aims: Data comparing the effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on type-2 diabetes (T2D) outcomes and the relationship between weight-loss (WL) and T2D remission are limited. Thus, we undertook a retrospective study of patients with obesity and T2D who underwent RYGB or SG and examined the relationship between 2-year (2y) post-surgery T2D and WL outcomes.Material & methods: Patients who underwent RYGB (...

Background: Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is a new method employed in the management of differentiated thyroid cancer (DTC). The integrated FDG-PET plus computed tomography (PET/CT) fusion imaging system seems able to provide some additional advantages over PET alone, mainly related to a better anatomical localisation of the hypermetabolic metastatic lesions. The influence of serum TSH levels on 18F-FDG uptake by recurrences o...

Obesity is a major cause of chronic hypoventilation and/or obstructive sleep apnea syndrome (OSAS). Aim of this study was to evaluate the prevalence of pulmonary dysfunction and the relationship between OSAS and several clinical, functional and polysomnographics parameters in severely obese patients. 101 subjects (68 females and 33 males) aged 49.2±13.2 years (mean±S.D.), with BMI 46.8±6.5 Kg/m2 were enrolled. Sleep quality and daytime ...

Obesity is a well established risk factor for congestive heart failure. The existence of an ‘obese cardiomyopathy’ has been hypothesized, as the complex combination of the effects of both hemodynamic and metabolic alterations. Aim of this study was to analyze the effect of bariatric surgery on the early myocardial alterations detected in a group of severe obese patients by high frame rate integrated backscatter (IBS). Twenty severely obese patients (5 males, 15 femal...

Background: The number of women seeking bariatric surgery in order to improve their fertility is increasing. Current guidelines recommend that pregnancy should be delayed for at least 1 year post-surgery. However, there are limited data regarding pregnancy outcomes post-surgery, particularly for sleeve gastrectomy.Methods: We performed a single-centre, retrospective cohort study of pregnancies in women post-bariatric surgery. Surgical and maternity recor...

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women, affecting up to 10% of women in reproductive age. The evidence of polycystic ovaries at ultrasonography has been recently considered as a further criteria to diagnose PCOS. In order to determine whether FSH receptor gene affects hormonal and/or metabolic parameters of PCOS women the presence of FSH receptor gene mutations was investigated. Forthy women aged between 18 and 40 years with poly...